The root apical meristem, or root apex, is a small region at the tip of a root in which all cells are capable of repeated division and from which all primary root tissues are derived. In anatomy the apical foramen is the opening at the apex of the root of a tooth, through which the nerve and blood vessels that supply the dental pulp pass. Thus it represents the junction of the pulp and the periodontal tissue. In immature teeth the root is not fully formed leading to an open apex.

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